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Osteoconductive Collagen Mineral Bone Graft Matrix

Highly Purified Carbonate Apatite Mineral

  • Superior to ß-tricalciumphosphate (ß-TCP) and hydroxyapatite (HA) as a bioresorbable bone graft substitute1
  • Resorption, remodeling and structure analogous to human bone2

Highly Purified Type I Collagen

  • Favorable influence on cellular infiltration and protein binding3
  • Resorbed and remodeled naturally in bone through normal metabolic pathways4


  1. Kanayama, K., Sriarj, W., Shimokawa, H., Ohya, K., Doi, Y., Shibutani, T. 2011. Osteoclast and Osteoblast Activities on Carbonate Apatite Plates in Cell Cultures. J Biomater Appl 2011 26:435-436.
  2. Matsuura A, Jubo T, Doi K, Hayashi K, Morita K, Toyota R, Hayashi H, Hirata I, Okazaki M, and Akagawa Y. 2009. Bone Formation Ability of Carbonate Apatite-Collagen Scaffolds with Different Carbonate Contents. Dental Materials Journal 28(2): 234-242.
  3. Geiger, M., Li, R.H., Friess, W. 2003. Collagen Sponges for Bone Regeneration with rhBMP-2. Advanced Drug Delivery Reviews 55: 1613-1629.
  4. Li, S.T., 2000. Biologic Biomaterials: Tissue-Derived Biomaterials (Collagen). Biomedical Engineering Handbook, Second Edition, Vol. I, JD Bronzino (ed). Pp 42:1-23, CRC Press, Boca Raton, FL.