Oral-Maxillofacial
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Kassolis JD, Reynolds MA. Evaluation of the adjunctive benefits of platelet-rich plasma in subantral sinus augmentation. J Cran Surg 2005;16(2):280-287.
Summary: 10 patients undergoing bilateral sinus augmentation received freeze-dried bone allograft and platelet rich plasma on one side and freeze-dried bone allograft and membrane on the other side. Core biopsy specimens and postoperative radiographs were obtained 4.5-6 months postoperatively. The PRP sides had significantly higher percentages of vital tissue, with less residual graft particles then the control group. PRP appeared to enhance the rate of bone formation compared to the control group.
Quotation: "The current histologic findings suggest that freeze-dried bone allograft in combination with PRP provides a viable therapeutic approach for subantral sinus augmentation in preparation for implant placement. Moreover, PRP appears to enhance the formation of bone after sinus grafting with freeze-dried bone allograft, consistent with adjunctive therapeutic benefit."
Lindeboom JA, Mathura K, Aartman I, et al. Influence of the application of platelet-enriched plasma in oral mucosal wound healing. Clin Oral Impl Res 2007;18:133-39.
Summary: 10 patients undergoing a bilateral sinus floor elevation had PRP applied on one side of the mouth with the other side receiving a placebo. Wound healing was significantly accelerated in the PRP-treated mucosal wounds during the first 10 days postoperative. The PRP appeared to induce a strong stimulatory effect on capillary regeneration.
Quotation: "The results of this study support the general concept that PRP not only improves bone regeneration as has been reported earlier in oral and maxillofacial surgeries but also accelerates microcirculatory angiogenesis after surgical injury, which subsequently leads to soft tissue repair."
Pomerantz J, Dutton JM. Platelet gel for endoscopic sinus surgery. Annals of Oncology, Rhinology, and Laryngology 2005;114(9):699-704.
Summary: 16 patients undergoing endoscopic sinus surgery received platelet gel for their sinus packing. They were matched with a cohort control population and the results of quality of life surveys were compared. Although not statistical significant due to the small sample size, the quality of life scores were superior for the platelet gel group compared to the control group.
Quotation: "Platelet gel is absorbable and does not require the removal and discomfort of gauze packing . . . In this study, we have found that patients prefer platelet gel and that platelet gel results in a better quality of life after surgery."