Plasmax™: Skull/Brain
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Nissen AJ, Johnson AJ, Perkins RC, Welsh JE. Fibrin glue in otology and neurotology. Ann J Otol 1993;14(2):147-50.
Summary: Authors discuss a number of applications of autologous fibrin slue including positioning and securing implants, closure of wound edges, and application as an adjunct to achieve dural closures during intracranial procedures. No adverse reactions were related to the use of autologous fibrin glue in the report series.
Quotation: “Autologous fibrin glue has a definite place in the otologic surgeon’s armamentarium. Although it is not yet the perfect adhesive, the current formulations have well-established usefulness. There is an exceedingly low risk of complications and toxic effects. It is reasonably simple to obtain and use in the typical operating room setting.”
Black FO, Pesznecker S, Norton T, Fowler L, Lilly DJ, Shupert C, Hemer WG, Peterka RJ, Jacobson ES. Surgical management of perilymphatic fistulas: a Portland experience. Am J Otol 1992;13(3):254-62.
Summary: An unacceptably high occurrence of perilymphatic fistula (PLF) recurrence after their surgical repair led the authors to develop a new technique for PLF closure. This technique included laser graft-site preparation and applying a “buttress” of autologous fibrin glue. This technique led to a significant improvement in surgical outcome, with recurrences dropping from 27 percent to 8 percent. Vertigo and disequilibrim improved in 89 percent and 84 percent of patiens, respectively.
Quotation: “We conclude that this new surgical technique is an important addition to the otologic surgeon's arsenal for PLF management.”
Sierra DH, Nissen AJ, Welch J. The use of fibrin glue in intracranial procedures: preliminary results. Laryngoscope 1990;100(4):360-3.
Summary: Autologous fibrin glue prepared from cryoprecipitate was used in eight intracranial procedures to prevent cerebrospinal fluid (CSF) leaks. After one year, none of the cases showed CSF leakage or adverse reaction to the fibrin glue.
Quotation: “The use of this autologous fibrin glue appears to provide an adjunct to commonly employed packing techniques in a convenient and effective manner. With more experience, fibrin glue might become an even more important tool in intracranial procedures.”
Toma AG, Fisher EW, Cheesman AD. Autologous fibrin glue in the repair of dural defects in craniofacial resections.
Summary: Autologous fibrin glue was used to prevent CSF leakage in twenty patients undergoing craniofacial resection for ethmoidal neoplasms. The fibrin glue was successful in preventing postoperative CSF leaks.
Quotation: “We recommend the use of autologous fibrin glue in craniofacial resections, and would anticipate its increasing use as an adhesive in other otorhinological procedures.”
Yuyama R, Mishima K, Fujimaki T, Suzuki I, Saski T, Ueno H, Shibata Y, Kirino T. Clinical experience of autologous blood transfusion and fibrin glue in neurosurgery. No Shinkei Geka 1998;26(8):685-90.
NOTE: Article is in Japanese.
Summary: Autologous fibrin glue was used in 70 patients to ensure dural closure during neurological procedures. CSF leakage was reported to be 16.5%, similar to previous reports in which other methods were used. The glue proved effective in four cases where it was used to transpose and fix vessels that received microvascular decompression.