Plasmax™: Review
Some of the information contained on this webpage pertains to products, indications for use of products and/or therapies that are only available outside the United States and have not been approved or cleared for marketing by the United States Food & Drug Administration.
Siedentop KH, Park JJ, Shah AN, Bhattacharyya TK, O’Grady KM. Safety and efficacy of currently available fibrin tissue adhesives. Am J Otolaryntol 2001;22(4):230-5.
Summary: Authors reviewed preparation methods, bonding power, preparation time, and costs associated with several different types of fibrin tissue adhesives, including autologous, single-donor homologous, and commercially-available. All preparations were safe with no infection or tissue reactions, and all were found to have similar biocompatibility and biodegradability in soft tissue tests. Although the homologous preparations had stronger bonding power, the autologous methods were more cost and time effective. The clinical indication will determine the optimal adhesive choice.
Quotation: “Whether used as an adhesive, hemostatic agent, sealant, or a carrier for growth factors or antibiotics, fibrin tissue adhesive (FTA) has gained widespread acceptance as an important and useful tool for a variety of surgical procedures.”
Spotnitz WD. Fibrin sealant in the United States: clinical use at the University of Virginia. Thromb Haemost 1995;74(1):482-5.
Summary: Single-donor and autologous fibrin sealant produced by the University of Virginia blood bank has been used in many different types of surgical procedures from 1985 to publication. The most popular procedures have been thoracic and cardiovascular, neurosurgery, and plastic surgery, and the fibrin sealant has been effective in 90% of patients. Many different possible applications, advantages, and disadvantages are discussed for different fibrin preparations.
Quotation: “Fibrin sealant has been an extremely effective and widely used adjunct to surgical operations. It has been applied successfully in more than 90% of cases and has been utilized in approximately 5% of the operations performed yearly at this institution.”
“Significant benefits to fibrin sealant use have been noted not only for control of bleeding but also for control of leakage of air and other body fluids. In addition, tissue apposition requirements can be achieved using fibrin sealant as is demonstrated in its ability to enhance skin graft survival.”