Plasmax™: Ear
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Moretz WH, Shea JJ, Emmett JR, Shea JJ III. A simple autologous fibrinogen glue for otologic surgery. Otolaryngol Head Neck Surg 1986;95(1):122-4.
Abstract: “A simple method of concentrating a patient's own fibrinogen for use with a thrombin/calcium solution--to produce a coagulum-type tissue glue for otologic surgery-- is presented. The principal advantages of this system include a simple modification of the cryoprecipitate technique, which can be easily performed in any hospital laboratory using a minimal amount of the patient's blood, and the use of autologous fibrinogen, which completely rules out the possibility of transmission of hepatitis or AIDS viruses. Useful tips on preparation and use of this autologous tissue glue, based on experience over the past 2 years, will be presented.”
Park MS. Autologous fibrin glue for tympanoplasty. Am J Otol 1994;15(5):687-9.
Summary: An attempt was made to create an improved autologous fibrin glue for use in middle ear surgery. Various formulations of autologous fibrin glue were evaluated for fibrinogen concentration, observed during production, and tested for bonding strength before being chosen for application in surgery. When used, the fibrin glue was an effective adjunct in middle ear surgery.
“Autologous fibrin glue of improved quality was produced under the proposed technical guidelines and used successfully as an adjunct in most cases of tympanoplasty.”
Silberstein LE, Williams LJ, Hughlett MA, Magee DA, Weisman RA. An autologous fibrinogen-based adhesive for use in otologic surgery. Transfusion 1988;28(4):319-21.
Summary: An autologous fibrin adhesive prepared by PEG precipitation from 40ml of whole blood was used successfully in otologic surgery in 12 patients.
Quotation: “Our preliminary data suggest that a fibrinogen-based adhesive derived by PEG precipitation deserves further investigation as a safe, effective, autologous adhesive with many potential surgical applications.”
Black FO, Pesznecker S, Norton T, Fowler L, Lilly DJ, Shupert C, Hemer WG, Peterka RJ, Jacobson ES. Surgical management of perilymphatic fistulas: a Portland experience. Am J Otol 1992;13(3):254-62.
Summary: An unacceptably high occurrence of perilymphatic fistula (PLF) recurrence after their surgical repair led the authors to develop a new technique for PLF closure. This technique included laser graft-site preparation and applying a “buttress” of autologous fibrin glue. This technique led to a significant improvement in surgical outcome, with recurrences dropping from 27 percent to 8 percent. Vertigo and disequilibrim improved in 89 percent and 84 percent of patiens, respectively.
Quotation: “We conclude that this new surgical technique is an important addition to the otologic surgeon's arsenal for PLF management.”